The staff of CPMI has maintained within our database, a population of patients with Hypertension. The size of this population varies from 200 to 300 patients. We have successfully performed skip phase 1 studies with antihypertensive drugs confining hypertensive patients for first time in man exposures. The Hypertensive patients age ranges from 35 to 80 years. Dr. Lasseter has successfully been the Principal Investigator of approximately 70 Hypertensive research studies.